Mutational Analysis of Selected Genes in the TGF , Wnt, pRb, and p53 Pathways in Primary Uveal Melanoma
نویسندگان
چکیده
PURPOSE. It is known that the pRb pathway cell-cycle inhibitor p16 plays a significant role in cutaneous melanoma and that alteration of p16, which resides within the 9p21-22 locus that also contains p15 and p14, may occur in up to one third of uveal melanomas. The absence of TGF responsiveness noted in cultured uveal melanoma cells also suggests that the TGF pathway plays a role in the formation of this tumor. Therefore, mutational screening was performed in several key genes in tumor-suppressor pathways that are known to be altered in some uveal melanomas.
منابع مشابه
Mutational analysis of selected genes in the TGFbeta, Wnt, pRb, and p53 pathways in primary uveal melanoma.
PURPOSE It is known that the pRb pathway cell-cycle inhibitor p16(INK4A) plays a significant role in cutaneous melanoma and that alteration of p16(INK4A), which resides within the 9p21-22 locus that also contains p15(INK4B) and p14(ARF), may occur in up to one third of uveal melanomas. The absence of TGFbeta responsiveness noted in cultured uveal melanoma cells also suggests that the TGFbeta pa...
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